Differential Regulation of Cytochrome C Release in Dexamethasone-Resistant 7TD1 Cells
نویسندگان
چکیده
منابع مشابه
Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.
Mitochondria in mammalian cells are well-known to play an important role in the intrinsic pathway of genotoxic-agent-induced apoptosis by releasing cytochrome c into cytosol and to be a major source of reactive oxygen species (ROS). The aim of this study was to examine whether mitochondrial ROS are involved in radiation-induced apoptotic signaling in A549 cells. Post-irradiation treatment with ...
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Truncated Bid (tBid) releases cytochrome c from mitochondria by inducing Bak (and Bax) pore formation in the outer membrane. An important issue is whether a second tBid action, independent of Bak and Bax, is also required to enhance cytochrome c mobility in the intermembrane spaces. To investigate this, we developed a kinetic analysis enabling changes in the diffusibility of cytochrome c in the...
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ژورنال
عنوان ژورنال: Journal of Cancer Therapy
سال: 2013
ISSN: 2151-1934,2151-1942
DOI: 10.4236/jct.2013.44095